Effect and underlying mechanism of Huangjing Qianshi decoction in pre-diabetes mouse model.

ABSTRACT:

Background

Insulin secretion deficiency and increased insulin resistance are key pathological pathways that lead to pre-diabetes. Without intervention, pre-diabetes can easily develop into type 2 diabetes mellitus. However, no specific medicine is available for treating pre-diabetes except for intervention through lifestyle changes. Huangjing Qianshi decoction (HJQST) is a qi-replenishing and yin-nourishing Chinese medicinal compound. However, the mode and mechanism of action of HJQST in improving pre-diabetes remain unclear. Here, we studied the effect of HJQST on pre-diabetes.

Methods

BKS-db mice were induced to develop pre-diabetes and treated with HJQST and metformin (MET). After treatment for 51 days, hematoxylin-eosin and oil red O staining were used to analyze the pat

SUBMITTER: Cai J 

PROVIDER: S-EPMC12020235 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature