Are liquid levothyroxine formulations comparable? The LETI study.

ABSTRACT:

Background

Liquid ethanol-containing levothyroxine (e-LT4) is known to circumvent malabsorption induced by food, drugs, or pathological conditions. Recently a new ethanol-free formulation of liquid levothyroxine (ef-LT4) has been commercialized. No studies have compared e-LT4 with ef-LT4. The aim of the present study is to compare thyroid hormone profile in patients treated with e-LT4 and ef-LT4.

Material and methods

We retrospectively retrieved thyroid hormonal profile and clinical data of 48 patients diagnosed with hypothyroidism who had been on stable treatment with an e- LT4 formulation at the same dosage for at least one year and who decided to switch to ef-LT4 for tasting issue.

Results

A significant increase in TSH levels was observed after 6 months on ef-LT4 t

SUBMITTER: Gatta E 

PROVIDER: S-EPMC12020242 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature