Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia.

ABSTRACT: With high disability and mortality rate as well as highly complex pathogenesis, cerebral ischemia is highly morbid, prone to recurrence. To comprehensively understand the pathophysiological process of cerebral ischemia and to find new therapeutic strategies, a new approach to cerebral ischemia transcriptomics has emerged in recent years. By integrating data from multiple levels of transcriptomics, such as transcriptomics, single-cell transcriptomics, and spatial transcriptomics, this new approach can provide powerful help in revealing the molecular mechanisms of cerebral ischemia occurrence and development. Key findings highlight the critical roles of inflammation, blood-brain barrier dysfunction, and mitochondrial dysregulation in cerebral ischemia, offering potential biomarkers and thera

SUBMITTER: Liu J 

PROVIDER: S-EPMC12020253 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature