Effect of methodological choices and inclusion criteria on network meta-analysis results in psoriasis.

ABSTRACT:

Background

When conducting network meta-analysis (NMA), researchers need to make several methodological and analytical decisions, which can influence the results of NMAs. Our objective was to evaluate the impact of different methodological choices on the conclusions from the analyses of a network of 20 active treatments in patients with psoriasis.

Methods

We re-analysed the available data of a living Cochrane NMA evaluating the systemic treatments in psoriasis under various analytical scenarios defined by the combination of pre-specified methodological choices. We performed NMAs on three outcomes: Psoriasis Area Severity Index (PASI) 90, PASI 100 and serious adverse events (SAEs). Variability of the effect estimates across NMAs was summarized using ratio of relative risks (R

SUBMITTER: Guelimi R 

PROVIDER: S-EPMC12020264 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature