Impacts of air pollutions on cardiovascular and cerebrovascular diseases through inflammation: a comprehensive analysis of one million Chinese and half million UK individuals.

ABSTRACT:

Background

Epidemiological studies have found an association between air pollution and cardiovascular and cerebrovascular diseases (CACD) and its subtypes. However, there is a lack of individual-level data to explore the associations of air pollutants on CACD and its subtypes, the interaction among them, and the potential mechanism.

Methods

This study employed a two-stage design, combining a time-stratified case-crossover study with a cohort study, analyzing data from one million individuals from China and half million from the UK. The study assessed the impact of air pollutants on CACD and its subtypes, while also examining the mediating effects of inflammation. Distributed lag non-linear models were used to analyze the lagged effects of pollutants, and mediation analysis w

SUBMITTER: Lin F 

PROVIDER: S-EPMC12020266 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature