Clinicopathological characteristics of transcription factor-defined subtypes in bladder small cell carcinoma.

ABSTRACT:

Background

Small cell carcinoma (SmCC) of the bladder is a rare and aggressive malignancy. Characterizing transcription factor (TF)-defined subtypes may provide insights into its biology and inform targeted therapies. This study investigates lineage-specific TF expression in bladder SmCC, its association with clinicopathological features, and comparisons with prostate SmCC.

Methods

A retrospective analysis was conducted on 9 cases of bladder SmCC and 6 cases of prostate SmCC diagnosed at a single cancer hospital in Japan. Immunohistochemistry was performed for lineage-specific TFs (ASCL1, NEUROD1, POU2F3, and YAP1) and neuroendocrine and other markers. Statistical comparisons were made using Fisher's exact test and independent samples t-tests.

Results

Combined SmCC mo

SUBMITTER: Kitahama K 

PROVIDER: S-EPMC12020276 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature