Causal relationship between atherosclerosis and inflammatory bowel disease risk: a two-sample Mendelian randomization study.

ABSTRACT:

Objective

This study was to evaluate the causal associations of atherosclerosis with the risk of inflammatory bowel disease (IBD), and its subtypes [ulcerative colitis (UC) and Crohn's disease (CD)]: a two-sample Mendelian randomization study.

Materials and methods

Single nucleotide polymorphism (SNPs) associated with atherosclerosis including CPAmax, CPSmax, brachial-femoral pulse wave velocity (bfPWV), coronary atherosclerosis, cerebral atherosclerosis, peripheral atherosclerosis, coronary artery disease (CAD) and ischemic stroke (IS) were identified from previous genome-wide association studies (GWAS). SNPs were strictly selected to fulfill the MR assumptions. The causal links between atherosclerosis and IBD were evaluated using inverse-variance weighted (IVW) as the prim

SUBMITTER: Guo W 

PROVIDER: S-EPMC12020298 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature