Vitamin A mediates FABP4 to regulate intramuscular fat production: a new target and strategy for optimizing beef quality.

ABSTRACT: Beef quality is critically determined by intramuscular fat (IMF) deposition. Retinoic acid (RA), the active metabolite of vitamin A, plays an essential regulatory role in IMF development. To systematically investigate RA-mediated regulation of IMF formation in cattle, we established a concentration gradient of RA supplementation and employed a systematic screening approach to identify the optimal dosage for modulating bovine intramuscular adipocytes (IMAs) proliferation and differentiation. Subsequently, leveraging integrated multi-omics approaches, we screened the key downstream molecular targets through which RA governs IMF biosynthesis, and clarified the potential regulatory mechanism of this target. Our experimental data establish that RA promotes the proliferation of IMAs through modu

SUBMITTER: Song Y 

PROVIDER: S-EPMC12020305 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature