Oxidative stress induced paclitaxel-derived carbon dots inhibit glioblastoma proliferation and EMT process.

ABSTRACT: Glioblastoma represents the most prevalent and deadly form of brain tumor with limited therapeutic drugs. The existence of the blood-brain barrier (BBB) hinders drugs permeate to the brain efficiently. Nowadays, nano-formulations, particularly carbon dots, have emerged as promising candidates for targeting and treating brain diseases. In this study, we report the synthesis of a novel carbon dots, PTX-CDs, using a one-step hydrothermal method with paclitaxel (PTX) as the precursor. PTX-CDs shows increased water solubility by about 1000 times in comparison with PTX. Moreover, PTX-CDs effectively penetrates the BBB and exerts significant anticancer effects. In detail, PTX-CDs accumulates in mitochondria of tumor cells without adding extra targeted molecules, resulting in the damage of mitocho

SUBMITTER: Yan H 

PROVIDER: S-EPMC12020310 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature