Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration.

ABSTRACT:

Background

Pre-eclampsia (PE) and pregnancy hypertension (PH) are common and serious complications during pregnancy, which can lead to maternal and fetal death in severe cases. Therefore, further research on the potential therapeutic targets of PE and PH is of great significance for developing new treatment strategies.

Methods

This study used the summary data-based Mendelian randomization (SMR) method to analyze expression quantitative trait loci (eQTL) data from blood, aorta, and uterus with Genome-wide association studies (GWAS) data on PE and PH, exploring potential genetic loci involved in PE and PH. Since proteinuria is a clinical manifestation of PE, we also analyzed genes related to the kidney and PE. The HEIDI test was used for heterogeneity testing, and results were

SUBMITTER: Yao H 

PROVIDER: S-EPMC12020376 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature