Evaluation of Postoperative Outcomes Following Early and Late Palate Repair: A Preclinical Study.

ABSTRACT:

Objective

To quantitatively assess the impact of early versus late surgical intervention on midfacial growth using a mouse model.

Methods

A full-thickness mucoperiosteal flap surgery was performed on newborn (P17) mice and on neonatal (P30) mice. High-resolution micro-computed tomographic imaging coupled with histomorphometric analyses was used to assess craniomaxillofacial growth. Histology and immunohistochemical analyses were used to assess cellular and molecular responses postsurgery.

Results

Early surgical intervention at P17 resulted in significant midfacial growth arrest, with pronounced maxillary hypoplasia. Histomorphometric analyses revealed significant (P < 0.05) growth disruptions in the mid-palatal suture complex, including premature removal of the cartil

SUBMITTER: Aellos F 

PROVIDER: S-EPMC12020392 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature