Arbitrary Design of DNA-Programmable 3D Crystals through Symmetry Mapping.

ABSTRACT: Nanoscale self-assembly offers exciting potential for creating intricate structures beyond the limits of traditional top-down nanofabrication. Despite advancements in molecularly programmable assembly, particularly utilizing DNA nanotechnology, challenges remain in defining precise assembly instructions for the formation of complex three-dimensional (3D) superlattice architectures. DNA-based self-assembly methods offer programmability through sequence-encoded addressable bonds, but the difficulty lies in reducing the complexity and number of these interactions to establish a modular, structural design strategy and streamline the assembly and component fabrication process. This work proposes a symmetry-mapping bond assignment algorithm to guide the design of arbitrarily prescribed 3D lattic

SUBMITTER: Kahn JS 

PROVIDER: S-EPMC12020415 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature