Induction of Epithelial-Mesenchymal Transition in Periodontitis Rat Model.

ABSTRACT:

Objectives

 Epithelial-mesenchymal transition (EMT) is a process that shifts cellular phenotype. It is linked to several different inflammatory diseases including periodontitis. This study was conducted to investigate the involvement of the EMT process in an experimental periodontitis (EP) model.

Materials and methods

 Second upper molars of Wistar albino male rats were ligated to induce periodontitis, while controls were not ligated. The animals were sacrificed after 0, 3, 7, 14, and 21 days (n = 6 for each time point). The maxillae were resected, posterior to the incisor teeth, and the gingival tissue surrounding teeth were analyzed. Alveolar bone loss (ABL), epithelial thickness, and the number of inflammatory cells were measured at each time point. Expressions of

SUBMITTER: Alanbari BF 

PROVIDER: S-EPMC12020583 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature