Surfactant Protein D and Club Cell Secretory Protein as Biomarkers of Disease Severity and Fostamatinib Efficacy in Severe COVID-19.

ABSTRACT:

Objectives

The objective of the study was to evaluate whether epithelial injury biomarkers-club cell secretory protein (CC16), surfactant protein D (SPD), surfactant protein A (SPA), and receptor for advanced glycation end-products (RAGE)-could prognosticate disease severity and predict treatment responses in hospitalized COVID-19 patients receiving fostamatinib.

Design

Retrospective analysis of samples collected from a randomized, placebo-controlled clinical trial evaluating the safety and efficacy of fostamatinib in hospitalized COVID-19 patients.

Setting

Hospitalized patients in a multicenter clinical trial.

Patients

Hospitalized COVID-19 patients requiring supplemental oxygen.

Interventions

Longitudinal measurement of soluble biomarkers of epithelial

SUBMITTER: Ramos-Benitez MJ 

PROVIDER: S-EPMC12020689 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature