Replicating a COVID-19 study in a national England database to assess the generalisability of research with regional electronic health record data.

ABSTRACT:

Objectives

To assess the degree to which we can replicate a study between a regional and a national database of electronic health record data in the UK. The original study examined the risk factors associated with hospitalisation following COVID-19 infection in people with diabetes.

Design

A replication of a retrospective cohort study.

Setting

Observational electronic health record data from primary and secondary care sources in the UK. The original study used data from a large, urbanised region (Greater Manchester Care Record, Greater Manchester, UK-2.8 m patients). This replication study used a national database covering the whole of England, UK (NHS England's Secure Data Environment service for England, accessed via the BHF Data Science Centre's CVD-COVID-UK/COVID-

SUBMITTER: Williams R 

PROVIDER: S-EPMC12020769 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature