Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy.

ABSTRACT:

Objectives

Absence seizures impair psychosocial function, yet their detailed neuronal basis remains unknown. Recent work in a rat model suggests that cortical arousal state changes prior to seizures and that single neurons show diverse firing patterns during seizures. Our aim was to extend these investigations to a mouse model with studies of neuronal activity and arousal state to facilitate future fundamental investigations of absence epilepsy.

Methods

We performed in vivo extracellular single unit recordings on awake head-fixed C3H/HeJ mice. Mice were implanted with tripolar electrodes for cortical electroencephalography (EEG). Extracellular single unit recordings were obtained with glass micropipettes in the somatosensory barrel cortex, while animals ambulated freely on a

SUBMITTER: Khan W 

PROVIDER: S-EPMC12020870 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature