Socioeconomic disparities and osteoarthritis impact hormone therapy adherence in breast cancer.

ABSTRACT:

Purpose

Adherence to adjuvant hormone therapy (AHT) is critical for improving survival in breast cancer patients. This study examines how socioeconomic disparities, osteoarthritis (OA), and OA symptom onset timing influence AHT adherence and survival outcomes.

Patients and methods

This retrospective cohort study included 33,142 women with invasive breast cancer (2011-2015) from the Korean National Health Insurance Service. Group-based trajectory modeling (GBTM) identified AHT adherence patterns based on the proportion of days covered (PDC) over five years. Competing risk regression and Cox models assessed the impact of socioeconomic factors, pre-treatment OA, NSAID use, and other variables on AHT discontinuation and survival.

Results

GBTM revealed two adherence patter

SUBMITTER: Jang BS 

PROVIDER: S-EPMC12020906 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature