Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank.

ABSTRACT:

Purpose

This study aimed to investigate the correlation between cardiovascular health (CVH), evaluated through the Life's Essential 8 (LE8) score, and the risk of new-onset age-related macular degeneration (AMD).

Methods

This longitudinal analysis included 271,274 participants who were free of both cardiovascular diseases and AMD at baseline. The LE8 score was classified into three categories: low (<50 points), moderate (50 to <80 points), and high (≥80 points), with higher scores indicating better CVH. Cox proportional hazards models were used to explore the relationships between the CVH and AMD incidence. Furthermore, the population attributable risk (PAR%) was calculated for CVH and each individual metric.

Results

During an average follow-up duration of 10.9 years,

SUBMITTER: Peng Y 

PROVIDER: S-EPMC12020950 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature