Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study.

ABSTRACT:

Purpose

We determined the association between Life's Essential 8 (LE8) scores and AMD incidence and ascertained whether genetic susceptibility modifies it.

Methods

This prospective cohort study included 268,634 UK Biobank study participants with high, moderate, or low cardiovascular health based on LE8 scores. High and low cardiovascular health corresponded to the lowest and highest cardiovascular disease risks, respectively. The hazard ratios (HRs) and 95% confidence intervals (CIs) for AMD were estimated using Cox proportional hazards models. The dose-response relationships were evaluated using restricted cubic spline analysis. Stratified analyses using the AMD-polygenic risk score categories were used to assess potential modification. A composite variable combined LE8 and

SUBMITTER: Wang W 

PROVIDER: S-EPMC12020978 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature