Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates.

ABSTRACT: Timing perception is a fundamental cognitive function that allows organisms to navigate their environment effectively, encompassing both prospective and retrospective timing. Despite significant advancements in understanding how the brain processes temporal information, the neural mechanisms underlying these two forms of timing remain largely unexplored. In this study, it aims to bridge this knowledge gap by elucidating the functional roles of various neuronal populations in the striatum and prefrontal cortex (PFC) in shaping subjective experiences of time. Utilizing a large-scale electrode array, it recorded responses from over 3000 neurons in the striatum and PFC of macaque monkeys during timing tasks. The analysis classified neurons into distinct groups and revealed that retrospective a

SUBMITTER: Liu X 

PROVIDER: S-EPMC12021029 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature