Sensory Encoding Alternates With Hippocampal Ripples across Cycles of Forebrain Spiking Cascades.

ABSTRACT: The brain's response to external events depends on its internal arousal states, which are dynamically governed by neuromodulatory systems and have recently been linked to coordinated spike timing cascades in widespread brain networks. At rest, both arousal fluctuations and spiking cascades are evident throughout the forebrain and play out over multisecond time scales. Here, by analyzing large-scale neural recording data collected by the Allen Institute, it is demonstrated that these intrinsic processes persist across the mouse brain even during periods of continuous visual stimulation. In the stationary animal, each quasi-periodic cascade cycle systematically influenced 1) the efficacy of encoding in visually responsive brain areas and 2) the incidence of memory-related hippocampal ripples

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12021030 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature