Biological Reinforced Concrete for Cartilage Repair With 3D Printing.

ABSTRACT: The development of biomimetic cartilage constructs (BCCs) with natural extracellular matrix (ECM) microenvironments and topological cues to accelerate the reconstruction of natural articular cartilage (NAC) after injury is challenging due to its complex structure, low cellular content, and less vascularity. Inspired by concrete rebar structure, a biomimetic cartilage named "biological reinforced concrete" is fabricated, with collagen fiber orientation transitioning from parallel to perpendicular, replicating the ECM microenvironments and complex construct of NAC. 3D-printed ultrafine fiber networks (UFNs) served as a degradable "biorebars", while a hybrid biohydrogel acted as "biocement". The stem cells are utilized as "bioactive aggregates". The biocement is developed by combining and scr

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12021066 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature