Implanted Microneedles Loaded with Sparfloxacin and Zinc-Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple-Negative Breast Cancer to Prevent Recurrence and Metastasis.

ABSTRACT: Recent investigations have underscored the significant role of manganese ions (Mn²⁺) in immunization, particularly through the activation of the cGAS-STING pathway, which enhances antitumor immune responses. However, the rapid metabolism of free Mn²⁺ following administration limits its effectiveness as an immune adjuvant. To address these challenges, microneedles (MNs) of hyaluronic acid containing Sparfloxacin (SP) and zinc-manganese sulfide (ZMS) are prepared for the postoperative in situ treatment of triple-negative breast cancer (TNBC) to prevent cancer recurrence and combat wound infection. ZMS/SP (ZS)-loaded MNs exhibit strong antimicrobial and antibiofilm properties that are crucial for preventing postoperative infections. Moreover, the generation of reactive o

SUBMITTER: Chu Z 

PROVIDER: S-EPMC12021102 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature