A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing.

ABSTRACT: The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation of inflammation levels, and prevention of bacterial infections. Therefore, a multifunctional wound dressing with antioxidant, local glycocontrol, and antibacterial properties is developed to promote diabetic wound healing. This dressing is constructed by co-loading gold-cerium oxide (AuCeO₂) dumbbells and glucose oxidase (GOx) into a reactive oxygen species (ROS)-sensitive hydrogel matrix (ACG gels). In this system, Au-CeO₂ dumbbells effectively eliminate ROS, protecting cells from oxidative stress-induced damage while exhibiting significant near-infrared photothermal antibacterial activity. Additionally, the controlled release of GOx decreases blood glucos

SUBMITTER: Zhou B 

PROVIDER: S-EPMC12021113 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature