In vivo assessment of the effect of gel containing lactic acid and glycogen on vaginal microbiota and pH of asymptomatic women of reproductive age.

ABSTRACT: Background Vaginal dysbiosis is considered a risk factor for the development of gynecological and obstetric complications. This study aimed to evaluate the effects of vaginal gel containing lactic acid on vaginal pH, microbiota composition, and Candida species in asymptomatic women of reproductive age.

Methods

55 menstruating women, with no gynecological complaints, participated in the study, using a gel containing lactic acid twice a week, for 8 weeks. Assessments were conducted before and after the intervention, including measurements of vaginal pH, Nugent score, vaginal microbiota characteristics (alpha diversity index and Community State Types [CSTs] classification), and identification of Candida species.

Results

At baseline, 36.4% of women exhibited CST type IV vaginal m

SUBMITTER: Campaner AB 

PROVIDER: S-EPMC12021183 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature