First-trimester exposure to macrolides and risk of major congenital malformations compared with amoxicillin: A French nationwide cohort study.

ABSTRACT:

Background

While macrolides are among the frequently prescribed antibiotics for pregnant women, evidence of their fetal safety remains conflicting. This study aimed to evaluate the risk of major congenital malformations (MCM) after first-trimester exposure to macrolides compared with amoxicillin, focusing on specific MCM subtypes.

Methods and findings

This nationwide cohort study used data from the Mother-Child EPI-MERES Register nested in the French Health Data System (SNDS). Pregnancies linked with their singleton live-born infants from January 1, 2010, and December 31, 2020, were included. The macrolide exposure group comprised pregnancies with one or more prescriptions filled for systemic macrolides (erythromycin, spiramycin, roxithromycin, josamycin, clarithromycin, and

SUBMITTER: Tran A 

PROVIDER: S-EPMC12021278 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature