Whole liver phase-based R2 mapping in liver iron overload within a breath-hold.

ABSTRACT:

Purpose

Diagnosis and treatment monitoring of iron overload increasingly relies on non-invasive MRI-based measurement of liver iron concentration (LIC). Liver R₂ mapping is known to correlate well with LIC. However, traditional spin-echo based R₂ mapping methods have drawbacks such as long acquisition times and limited volumetric coverage. In this work, we present an optimized phase-based R₂ mapping method to quantify whole-liver R₂ in iron overload patients within a single breathhold.

Theory and methods

A recently developed phase-based R₂ mapping method is optimized in this study to improve estimation of high R₂ values using reduced TR, spatial averaging, and R₁ correction. Using Bloch equation sim

SUBMITTER: Tamada D 

PROVIDER: S-EPMC12021320 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature