Interpretation of inhomogeneous magnetization transfer in myelin water using a four-pool model with dipolar reservoirs.

ABSTRACT:

Purpose

To confirm ihMT's specificity to myelin, an ihMT presaturation module was combined with a Poon-Henkelman multi-echo spin-echo readout to separate the ihMT signal in myelin water from intra-/extra-cellular water. This study explored the relationship between two quantitative myelin imaging techniques and measured the ihMT signal of myelin water.

Methods

Six rats were injured; three were sacrificed three weeks post-injury, and three were sacrificed eight weeks post-injury, and three healthy control rats were also sacrificed. The nine formalin-fixed rat spinal cords were imaged using a Poon-Henkelman multi-echo spin-echo readout with an ihMT prepulse at different strengths of T1D$$ {T}_{1D} $$ filtering at 7T.

Results

The proposed model was able to characterize th

SUBMITTER: Lam MH 

PROVIDER: S-EPMC12021340 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature