RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation.

ABSTRACT: Macrophages are crucial in the body's inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS-p110α signalling pathway, known for its involvement in various biological processes and tumourigenesis, regulates two vital aspects of the inflammatory response in macrophages: the initial monocyte movement and later-stage lysosomal function. Disrupting this pathway, either in a mouse model or through drug intervention, hampers the inflammatory response, leading to delayed resolution and the development of more severe acute inflammatory reactions in live models. This discovery uncovers a previously unknown role of the p110α isoform in immune regulation within macrophages, offering insight into the complex mechanisms governing th

SUBMITTER: Rosell A 

PROVIDER: S-EPMC12021417 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature