Bidirectional Interaction Between Chronic Kidney Disease and <i>Porphyromonas gingivalis</i> Infection Drives Inflammation and Immune Dysfunction.

ABSTRACT: Introduction: Chronic kidney disease (CKD) is characterized by a decline in renal function, increased mortality, and significant impairments in the immune system and function of immune cells. These alterations are often derived by uremic toxins, which, in turn, modify the immune system's response to infections. Our research investigates the progression of Porphyromonas gingivalis (P. gingivalis) infection during CKD and its subsequent impact on kidney failure. Methods: We utilized two infectious models, a chamber model representing short-term local inflammation and alveolar bone loss that mimic chronic infection of periodontium, both in conjunction with a CKD model. Additionally, our in vitro studies employed primary macrophages, osteoclasts, and lymphocytes to

SUBMITTER: Adamowicz K 

PROVIDER: S-EPMC12021489 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature