Head-to-head comparison of ⁶⁸Ga-PSMA-11 and ¹⁸F-FDG in delayed PET/CT imaging in prostate cancer diagnosis.

ABSTRACT:

Purpose

Delayed PET/CT imaging with ⁶⁸Ga-PSMA-11 is valuable in the detection of primary prostate (PCa) lesions and the differentiation of suspicious lesions. However, ¹⁸F-FDG PET/CT has been overlooked due to its low sensitivity to PCa during routine examination. This study aimed to compare the clinical impact of PSMA and FDG in delayed PET/CT imaging in PCa diagnosis.

Methods

Between 2019 and 2024, 65 PCa patients who underwent early (1 h post-injection) and delayed (3 h p.i.) PSMA and FDG scans were retrospectively analyzed. The delayed scans were conducted to clarify unclear findings in early scans or to increase the tumor lesions uptake in negative early scans. All patients were asked to drink 1 L of water between early and delayed scans. The numbe

SUBMITTER: Hu B 

PROVIDER: S-EPMC12021635 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature