Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans.

ABSTRACT: Environmental thermal stress substantially affects cellular plasticity of thermogenic adipocytes and energy balance through transcriptional and epigenetic mechanisms in rodents. However, roles of cold-adaptive epigenetic regulation of brown adipose tissue (BAT) in systemic energy metabolism in humans remained poorly understood. Here we report that individuals whose mothers conceived during cold seasons exhibit higher BAT activity, adaptive thermogenesis, increased daily total energy expenditure and lower body mass index and visceral fat accumulation. Structural equation modelling indicated that conception during the cold season protects against age-associated increase in body mass index through BAT activation in offspring. Meteorological analysis revealed that lower outdoor temperatures an

SUBMITTER: Yoneshiro T 

PROVIDER: S-EPMC12021649 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature