Reactive oxygen species-related oxidative changes are associated with splenic lymphocyte depletion in Ebola virus infection.

ABSTRACT: The dysregulated production of reactive oxygen species (ROS) during viral infections may lead to immune cell death and ineffective host responses. ROS dynamics have been under-investigated in severe Ebola virus disease (EVD), a condition in which hyperinflammation and excessive immune cell death are well described but poorly understood. Through ex vivo immunohistochemistry and in vivo ROS-sensitive magnetic resonance imaging (MRI) we demonstrate significant ROS-related oxidative changes in the spleens of domestic ferrets exposed to Ebola virus (EBOV). By immunohistochemistry or MRI, detection of splenic ROS was inversely correlated with the number of CD4⁺/CD8⁺ T lymphocytes and apoptotic CD8⁺ lymphocytes, but detection was positively correlated with the fre

SUBMITTER: Mani V 

PROVIDER: S-EPMC12021656 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature