GMIP: A Novel Prognostic Biomarker Influencing Immune Infiltration and Tumour Dynamics Across Cancer Types.

ABSTRACT: GMIP, a member of the RhoGAP family, plays a critical role in cytoskeletal remodelling, cell migration and immune modulation. Its aberrant expression in cancers suggests a pivotal role in tumour progression. GMIP expression was assessed using transcriptomic datasets from GDC and UCSC XENA, and protein distribution across tissues via HPA and GeneMANIA. The TISCH database identified primary GMIP-expressing cell types in the tumour microenvironment. Univariate Cox regression assessed GMIP's prognostic potential, while cBioPortal and GSCA explored genomic alterations. TIMER 2.0 was used to investigate immune cell infiltration and GMIP's role in immune regulation. GSEA and GSVA unveiled GMIP-related biological pathways, and molecular docking with CellMiner identified potential drug interactions

SUBMITTER: Jiang C 

PROVIDER: S-EPMC12021672 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature