Comparative microRNAs profile of Schistosoma japonicum male worms derived from single-sex and bisexual infections: Implications of the multifunctional role of microRNA.

ABSTRACT: Schistosoma japonicum is a dioecious parasite that requires constant pairing between male and female worms for female maturation and egg production. MicroRNAs (miRNAs) play crucial roles in regulating various biological processes, including parasite development and host-pathogen interactions, but their functions in schistosomes remain largely unexplored. This study aimed to investigate the differentially expressed miRNAs (DEMs) between mated male (MM) and single-sex male (SM) worms to gain insights into their regulatory roles in schistosome reproduction. Total RNA was extracted from 28-day-old MM and SM worms, followed by small RNA sequencing to identify DEMs. Bioinformatics analyses were used to predict the biological functions of DEM target genes. Comparative analysis with previously pub

SUBMITTER: Zhong H 

PROVIDER: S-EPMC12021732 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature