Pan-vaccinomics strategy for developing a universal multi-epitope vaccine against endocarditis-related pathogens.

ABSTRACT:

Introduction

Endocarditis is a life-threatening infection of the heart valves, frequently caused by pathogenic bacteria. The growth of multidrug-resistant bacteria necessitates the development of innovative therapeutic techniques, such as vaccines.

Methods

The current study employed core proteome analysis and a computational-based reverse vaccinology approach across multiple bacterial pathogens associated with endocarditis to identify prospective universal vaccine candidates. The core proteome analysis contained 121 highly pathogenic strains from ten distinct pathogens (Streptococcus mutans, Streptococcus viridans, Streptococcus pyogenes, Staphylococcus aureus, Enterococcus faecalis, Streptococcus agalactiae, Gemella morbillorum</

SUBMITTER: Chao P 

PROVIDER: S-EPMC12021834 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature