Identification of cellular senescence-related genes as biomarkers for lupus nephritis based on bioinformatics.

ABSTRACT:

Background

Lupus nephritis (LN) is one of the most common and severe complications of systemic lupus erythematosus with unclear pathogenesis. The most accurate diagnosis criterion of LN is still renal biopsy and nowadays treatment strategies of LN are far from satisfactory. Cellular senescence is defined as the permanent cell cycle arrest marked by senescence-associated secretory phenotype (SASP), which has been proved to accelerate the mobility and mortality of patients with LN. The study is aimed to identify cellular senescence-related genes for LN.

Methods

Genes related to cellular senescence and LN were obtained from the MSigDB genetic database and GEO database respectively. Through differential gene analysis, Weighted Gene Go-expression Network Analysis (WGCNA) and mach

SUBMITTER: Chen W 

PROVIDER: S-EPMC12021929 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature