Multi-ancestry sequencing-based genome-wide association study of C-reactive protein in 513,273 genomes.

ABSTRACT: C-reactive protein (CRP) serves as a pivotal marker of systemic inflammation, yet its genetic architecture has predominantly been explored within European populations. Our multi-ancestry sequencing-based genome-wide association study (seqGWAS) meta-analysis encompasses 447,369 Europeans, 10,389 Africans, 9685 Asians, and 9200 Hispanics in the discovery set, and 23,521 Europeans, 7160 Africans, 771 Asians, and 5178 Hispanics in the replication set. We identify 113 independent association signals (P_discovery ≤ 5 × 10^-9 and P_replication ≤ 0.05), including 21 loci that passed the conditional analysis, among which 3 are European-specific. Cross ancestry fine-mapping pinpoints 19 of 113 independent signals within the 95% credible set. Functional annotation reveal

SUBMITTER: Li H 

PROVIDER: S-EPMC12022081 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature