Altering ROY polymorph crystallization in conventional and microfluidic crystallizers with acoustic cavitation.

ABSTRACT: Selective crystallization of polymorphs can be a difficult task, influenced by several physical and chemical parameters like mixing, temperature, supersaturation, solvent, etc. Acoustic cavitation, produced at low ultrasonic frequencies, induces effects like micro-mixing and local heating which, when coupled to crystallization, can alter crystal form nucleation. In this work, anti-solvent crystallization of a model compound (ROY) was conducted to investigate the effect of acoustic cavitation on polymorph nucleation. Experiments were conducted in batch and microfluidic flow crystallization setups at different anti-solvent volume fractions under silent and sonicated conditions. Results show that sonication has a significant effect on the polymorphic outcome. In batch crystallization sonicati

SUBMITTER: Hussain MN 

PROVIDER: S-EPMC12022130 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature