Comprehensive assessment of aortic flow before and after aortic valve replacement in an ex vivo porcine model with four-dimensional flow magnetic resonance imaging.

ABSTRACT:

Objectives

Aortic valve replacement (AVR) has shown to induce secondary flow patterns deviating from main flow. It is impossible to analyse the impact of surgical access and different AVR techniques under standardized conditions in patients or silicone models. Therefore, we developed an ex vivo swine model to analyse the impact of surgical access and to compare flow patterns after different AVR techniques within the ascending aorta.

Methods

Porcine aortas (n = 6) were anastomosed to a custom-made piston pump. The pulse duplicator perfused the aortas with a blood-mimicking fluid at 2.5 l/min and 64 bpm. 4D flow magnetic resonance imaging of each aorta was acquired prior to surgery (NAV, n = 6), after sham surgery (aortotomy and closure thereof without valve replacement, NAV-A

SUBMITTER: Saisho H 

PROVIDER: S-EPMC12022217 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature