Clinically meaningful benefit and real-world evidence in Alzheimer's disease research and care.

ABSTRACT: In the realm of medical research, assessing novel therapies extends beyond statistical significance. The concept of meaningful benefits plays a pivotal role in determining the practical impact of interventions on patient outcomes. Clinical trials, which form the bedrock of evidence-based medicine, guide treatment decisions and shape health-care practices. While statistical significance remains a fundamental criterion, it falls short in fully evaluating the clinical relevance of therapeutic interventions. Clinically meaningful benefits focus on tangible improvements in patient health and well-being, transcending mere statistical thresholds. Key considerations include survival rates, symptom relief, functional status, and other patient-oriented outcomes. Determining meaningful benefits varie

SUBMITTER: Perneczky R 

PROVIDER: S-EPMC12022225 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature