Heterogeneity of morphometric similarity networks in health and schizophrenia.

ABSTRACT: Reduced structural network connectivity is proposed as a biomarker for chronic schizophrenia. This study assessed regional morphometric similarity as an indicator of cortical inter-regional connectivity, employing longitudinal normative modeling to evaluate whether decreases are consistent across individuals with schizophrenia. Normative models were trained and validated using data from healthy controls (n = 4310). Individual deviations from these norms were measured at baseline and follow-up, and categorized as infra-normal, normal, or supra-normal. Additionally, we assessed the change over time in the total number of infra- or supra-normal regions for each individual. At baseline, patients exhibited reduced morphometric similarity within the default mode network compared to healthy contr

SUBMITTER: Janssen J 

PROVIDER: S-EPMC12022303 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature