ZFP36 regulates the osteogenic differentiation of adipose-derived mesenchymal stem cells in osteoporosis by mediating KLF3 mRNA degradation.

ABSTRACT: Osteoporosis is one of the most common bone-related diseases in which osteogenic differentiation plays a key role. Adipose-derived mesenchymal stem cells (ADMSCs), as one of the important sources of bone formation, can differentiate into osteoblasts under appropriate conditions. To investigate the effect and potential mechanism of ZFP36 on osteogenic differentiation of ADMSCs in osteoporosis by regulating the stability of KLF3 mRNA. In this study, an osteoporosis rat model was established by ovariectomy (OVX), and the expression level of KLF3 in bone tissue was detected by RT-qPCR and immunohistochemistry (IHC). To further investigate the effect of KLF3 gene knockdown on bone health in osteoporotic rats. In vitro, KLF3 over-expression was performed on ADMSCs, and the effect of KLF3 knockdo

SUBMITTER: Liu C 

PROVIDER: S-EPMC12022323 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature