Blood Virome After Allogeneic Hematopoietic Stem Cell Transplantation.

ABSTRACT:

Background

Haploidentical allogeneic hematopoietic cell transplant recipients (allo-HCTr) receiving posttransplant cyclophosphamide (haplo-PTCy) are at higher risk for infectious complications, including viral infections.

Methods

We performed a retrospective, single-center, propensity-score matched-pair study including adult haplo-PTCy and allo-HCTr from human leukocyte antigen (HLA)-matched donors, undergoing transplantation in our institution between 2016 and 2022. For each patient, 4 blood samples (day [D] 0, D30, D90, and D180 posttransplantation) were extracted from the biobank and tested with metagenomic next-generation sequencing (mNGS) to describe the blood virome and identify viral RNA/DNA signatures potentially unrecognized by routinely available tests. Routine and

SUBMITTER: Hosszu-Fellous K 

PROVIDER: S-EPMC12022476 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature