Serine mistranslation induces the integrated stress response through the P stalk.

ABSTRACT: Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that support robust and accurate protein synthesis. A rapidly expanding number of studies show that mutations in aaRSs lead to multiple human diseases, including neurological disorders and cancer. How aaRS mutations impact human health is not fully understood. In particular, our knowledge of how aminoacylation errors affect stress responses and fitness in eukaryotic cells remains limited. The integrated stress response (ISR) is an adaptive mechanism in response to multiple stresses. However, chronic activation of the ISR contributes to the development of multiple diseases such as neuropathies. In this study, we show that Ser misincorporation into Ala and Thr codons, resulting from either aaRS-editing defects or mutations in tRNAs, ac

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12022490 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature