Examining the association between sleep apnea and total hippocampal volumes in cognitive impairment.

ABSTRACT:

Introduction

The prevalence of dementia is rising due to an aging population. Given the known risks of obstructive sleep apnea (OSA) on cerebrovascular health, we hypothesized that markers of OSA would correlate with reduced hippocampal volumes in individuals with cognitive impairment due to neurodegenerative, vascular, or mixed (NVM) etiologies.

Methods

Data from 166 patients were retrospectively analyzed. Participants underwent polysomnography or home sleep apnea tests, alongside structural brain magnetic resonance imaging (MRI). They were categorized into cognitive impairment due to NVM etiology or subjective cognitive complaints. Multiple linear regression models examined correlations between sleep variables and hippocampal volume.

Results

The presence of OSA, tim

SUBMITTER: Settimi M 

PROVIDER: S-EPMC12022498 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature