Plasma p-tau212 as a biomarker of sporadic and Down syndrome Alzheimer's disease.

ABSTRACT:

Background

All individuals with Down syndrome (DS) will develop full-blown Alzheimer´s disease (AD) pathology by age 40. Several genes encoded in chromosome 21, including dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), have been proven to contribute to the pathology. Phosphorylation of tau at threonine-212 (p-tau212) is very sensitive to DYRK1A phosphorylation and is increased in DSAD brain lysates. Here, we assessed the potential of this biomarker in DSAD and sporadic AD.

Methods

Using single molecule array (Simoa) technology, we tested p-tau212 and p-tau181 (n = 245 for plasma, n = 114 matching cerebrospinal fluid [CSF] samples).

Results

We have confirmed that the levels of plasma p-tau212 are increased in the DS population and sporadic AD ca

SUBMITTER: Kac PR 

PROVIDER: S-EPMC12022499 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature