Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study.

ABSTRACT:

Introduction

This study explored the relationship between blood biomarkers of cerebrovascular function and small vessel disease (SVD) neuroimaging markers and cognitive outcomes in highly-phenotyped participants.

Methods

We conducted cross-sectional and 1-year longitudinal analyses on 181 patients with mild ischemic stroke, enriched for SVD features. We examined relationships between a panel of 13 blood biomarkers and magnetic resonance imaging (MRI) markers of SVD (structural lesions, diffusion-weighted imaging [DWI]-positive lesions, blood-brain barrier (BBB) permeability, and cerebrovascular reactivity (CVR), and cognition.

Results

In linear mixed models, vascular endothelial growth factor was significantly associated with incident DWI-positive lesions over 1 year.

SUBMITTER: Jaime Garcia D 

PROVIDER: S-EPMC12022501 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature