Mitochondrial damage mediates STING activation driving obesity-mediated atrial fibrillation.

ABSTRACT:

Aims

Obesity is a significant risk factor for atrial fibrillation (AF), but the mechanisms by which obesity contributes to AF are not fully understood. Recent studies have indicated that the Stimulator of Interferon Genes (STING) signalling, mediated by mitochondrial damage, plays a crucial role in cardiac remodelling in various metabolic and cardiovascular diseases. This study aims to explore the role of STING in obesity-mediated AF and its potential mechanisms.

Methods and results

In this study, rats were divided into four groups: two groups received tail vein injections of AAV9-cTnT-STING siRNA and were fed either a normal diet or a high-fat diet (HFD) for 12 weeks; the other two groups received injections of AAV9-cTnT-NC siRNA and were similarly fed either a normal diet

SUBMITTER: Cao Z 

PROVIDER: S-EPMC12022609 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature