Aberrant preparation of hand movement in schizophrenia spectrum disorder: an fMRI study.

ABSTRACT: Schizophrenia spectrum disorder is linked to impaired self-other distinction and action feedback monitoring, largely stemming from sensory-motor predictive mechanisms. However, the neural correlates of these predictive processes during movement preparation are unknown. Here, we investigated whether patients with schizophrenia spectrum disorder exhibit aberrant sensory-motor predictive processes reflected in neural activation patterns prior to hand movement onset. Functional MRI data from patients with schizophrenia spectrum disorder (n = 20) and healthy controls (n = 20) were acquired during actively performed or passively induced hand movements. The task required participants to detect temporal delays between their movements and video feedback, which either displayed their o

SUBMITTER: Rashid HA 

PROVIDER: S-EPMC12022610 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature